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The staff centered on blocking a protein known as synaptotagmin-2, or Syt2. Syt2 is observed on the surface area of the granules made up of mucin. Fusion of these granules Using the cell membrane relies on Syt2 interacting with proteins while in the cell membrane.
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The Dickey laboratory then employed an aerosolized Edition in a very mouse model to confirm the drug minimized mucin secretion and airway blockage by mucus. Importantly, SP9 didn't affect the slow-release pathway for regular mucin secretion.
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